Comparison of the effects of aerobic exercise and computer-based cognitive stimulation in patients with schizophrenia - A randomized controlled trial
Journal of Psychiatric Research, cilt.195, ss.123-132, 2026 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 195
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.jpsychires.2026.01.039
- Dergi Adı: Journal of Psychiatric Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, BIOSIS, EMBASE, Psycinfo
- Sayfa Sayıları: ss.123-132
- Anahtar Kelimeler: Aerobic exercise, Cognition, Cognitive stimulation, Schizophrenia
- Maltepe Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to compare of the effects of aerobic exercise (AE) and computer-based cognitive stimulation (CS) in terms of cognition, clinical symptoms, depression, and quality of life (QOL) in patients with schizophrenia. Methods: A total of 58 individuals diagnosed with schizophrenia completed to the study (aerobic exercise group (AEG): n = 18, cognitive stimulation group (CSG): n = 20, control group (CG): n = 20). The AEG participated in a 12-week AE program, whereas the CSG engaged in computer-based CS over the same period. Also, the CG did not receive any intervention. Cognition with Montreal Cognitive Assessment scale and Frontal Assessment Battery, clinical symptoms with Positive and Negative Syndrome Scale, depression with Calgary Depression Scale for Schizophrenia, and QOL with Quality of Life Scale for Schizophrenia Patients scale were assessed at baseline and post-intervention. Results: Within-group improvements were observed in general cognitive function, clinical symptoms, and selected QOL domains in the AEG, whereas the CSG showed significant improvements across cognitive functions, clinical symptoms, depressive symptoms, and multiple QOL domains. In contrast, the CG exhibited significant deterioration in cognitive functions, selected clinical symptoms, depressive symptoms, and certain QOL domains over the 12-week period. Between-group comparisons revealed no statistically significant differences in general cognitive function, executive function, and depression at week 12. However, significant differences were observed in specific PANSS and QOL subscales. Conclusions: These findings suggested that computer-based CS and AE may offer domain-specific and complementary effects in cognitive and clinical domains in PwS.