A redundant function for the N-terminal tail of Ndc80 in kinetochore-microtubule interaction in Saccharomyces cerevisiae

Demirel, PINAR; Keyes, Brice; Chaterjee, Mandovi; Remington, Courtney; Burke, Daniel

doi:10.1534/genetics.112.143818

A redundant function for the N-terminal tail of Ndc80 in kinetochore-microtubule interaction in Saccharomyces cerevisiae

Demirel P. B., Keyes B. E., Chaterjee M., Remington C. E., Burke D. J.

Genetics, cilt.192, sa.2, ss.753-756, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 192 Sayı: 2
Basım Tarihi: 2012
Doi Numarası: 10.1534/genetics.112.143818
Dergi Adı: Genetics
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.753-756
Maltepe Üniversitesi Adresli: Hayır

Özet

The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating a redundant function for the Ndc80 and Dam1 complexes in vivo. © 2012 by the Genetics Society of America.