Aggregate Index of Systemic Inflammation and Systemic Inflammatory Response Index: Could be Potential Biomarkers to Monitor Bipolar Disorder Patients? An Observational Study Sistemik Enflamasyonun Toplam İndeksi ve Sistemik Enflamatuvar Yanıt İndeksi; Bipolar Bozukluk Hastalarını İzlemek için Potansiyel Biyobelirteçler Olabilir mi? Gözlemsel Bir Çalışma
Medical Journal of Bakirkoy, cilt.21, sa.2, ss.207-214, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/bmj.galenos.2024.2024.3-4
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.207-214
- Anahtar Kelimeler: aggregate index of systemic inflammation, Bipolar disorder, erythrocyte indices, inflammation, mean platelet volume, neutrophil to lymphocyte ratio, systemic inflammatory response index
- Maltepe Üniversitesi Adresli: Evet
Özet
Objective: Bipolar disorder (BD) is a severe psychiatric disorder characterized by recurrent episodes of mania and depression. Studies have reported the involvement of inflammatory processes in the pathophysiology of BD. This study aims to demonstrate that certain inflammatory markers are elevated in BD patients and to highlight their potential for use in diagnosis, prognosis, and treatment monitoring. Methods: This study included 57 BD patients and 121 healthy controls (HC). All participants underwent a complete blood count. Subsequently, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) values were calculated. The ethics committee approval for the study was obtained from Maltepe University Faculty of Medicine on January 19, 2022, number 2022/900/02. Results: The NLR, mean platelet volume (MPV), red cell distribution width (RDW), AISI, and SIRI values were higher in BD patients compared to HC. No significant differences were found in MLR, PLR, and SII levels between the BD and HC groups. Conclusion: Higher NLR, MPV, RDW, AISI, and SIRI values in BD patients than HC suggest increased inflammatory processes in BD. NLR, MPV, RDW, SIRI, and AISI are believed to be involved in the pathophysiology of BD and hold potential as biomarkers for monitoring disease prognosis and treatment efficacy. To further understand the underlying mechanism of BD, additional longitudinal studies are needed to determine how BD impacts inflammatory processes.