Antifungal activity of Pseudomonas aeruginosa and diphtheria toxin
Gazi Universitesi Eczacilik Fakultesi Dergisi, cilt.18, sa.1, ss.59-62, 2001 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 1
- Basım Tarihi: 2001
- Dergi Adı: Gazi Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.59-62
- Anahtar Kelimeler: Antifungal activity, Diphtheria toxin, Pseudomonas aeruginosa
- Maltepe Üniversitesi Adresli: Hayır
Özet
In vitro susceptibility studies revealed significant inhibition by Pseudomonas aeruginosa on the Candida species. The exact mechanism of this inhibition is still unknown. As the mechanisms of the toxins of Corynebacterium diphtheria and P. aeruginosa are known to be similar, the antifungal activity of P. aeruginosa and toxin producing vaccine strain Corynebacterium diphtheria on various Candida species were studied. The strains included in the study were; 9 strains of P.aeruginosa, a standard strain P.aeruginosa ATCC 27853, toxin producing vaccine strain C.diphtheria G12/6 and 6 strains of fungi Candida albicans, Candida tropicalis, Candida parapsilosis, Candida kefyr, Candida rugosa, Candida guilliermondii. The antifungal activity of P.aeruginosa strains were found to be 60% complete inhibition on C.albicans, 10% partial and 50% complete inhibition on C.parapsilosis, 10% complete and 50% partial inhibition on C.rugosa, 30% complete and 50% partial inhibition on C.guilliermondii, 30% complete and 40% partial inhibition on C.tropicalis, 50% complete and 10% partial inhibition on C.kefyr species. On the other hand, there had been no antifungal activity determined on these Candida strains in this study with diphtheria toxin.