The utility of serial plasma sE-selectin measurements in the prediction of retinopathy of prematurity in premature infants
Early Human Development, cilt.90, sa.9, ss.517-521, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 90 Sayı: 9
- Basım Tarihi: 2014
- Doi Numarası: 10.1016/j.earlhumdev.2014.03.009
- Dergi Adı: Early Human Development
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.517-521
- Anahtar Kelimeler: Preterm, Retinopathy of prematurity, SE-selectin
- Maltepe Üniversitesi Adresli: Evet
Özet
Background: sE-selectin has recently been suggested as a surrogate marker for prediction of ROP development. Aims: The possible role of serial plasma sE-selectin measurements in early prediction and diagnosis of ROP was evaluated. Study Design: Prospective observational study. Subjects: Forty six preterm infants aged <. 34. weeks of gestation and weighing <. 1500 g were enrolled. Of these, 26 constituted the ROP group and 20 constituted the no-ROP group. sE-selectin levels were measured serially in blood samples on the 1st day and on 14th and 28th postnatal days. Outcome measures: The primary outcome measure was to evaluate the role of sE-selectin concentrations in prediction of ROP. Results: The mean gestational age and birth weight were significantly lower in the ROP group. The mean sE-selectin concentrations in ROP group were significantly greater than those in no-ROP group at each time point (1st, 14th and 28th days of postnatal life). A receiver operating characteristic (ROC) analysis showed that at a plasma concentration of ≥. 86. ng/mL on the 1st postnatal day, sE-selectin had a sensitivity of 100% and a specificity of 94.1% with a positive predictive value of 96.3% and a negative predictive value of 100%. Plasma sE-selectin concentrations were significantly greater in infants who developed ROP in three different time points. Conclusions: This study shows for the first time that measurement of plasma sE-selectin concentrations as early as the first day of life might help identify preterm infants at risk of ROP. © 2014 Elsevier Ltd.