Cutaneous drug eruptions by current antiepileptics: Case reports and alternative treatment options
Clinical Neuropharmacology, cilt.31, sa.2, ss.93-96, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 2
- Basım Tarihi: 2008
- Doi Numarası: 10.1097/wnf.0b013e31806ad6cb
- Dergi Adı: Clinical Neuropharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.93-96
- Anahtar Kelimeler: Drug eruptions, Gabapentin, Lamotrigine, Leukocytoclastic vasculitis, TEN
- Maltepe Üniversitesi Adresli: Evet
Özet
Serious cutaneous drug eruptions due to antiepileptics have been defined for many drugs like carbamazepine, diphenylhydantoin, phenytoin and valproate. In recent years, adverse cutaneous reactions due to the current antiepileptic drugs have also been reported. In this paper, two cases are presented: a 48-year-old female receiving gabapentin for postherpetic neuralgia who developed leukocytoclastic vasculitis after 8 weeks and a 23-year-old male receiving lamotrigine for epileptic seizures who developed toxic epidermal necrolysis (TEN) in 15 days. Alternative therapy approaches with practical suggestions are also discussed. © 2008 Lippincott Williams & Wilkins, Inc.