The influence of HCG treatment on testicular apoptosis and fertility index in an experimental cryptorchidism model
Nobel Medicus, cilt.6, sa.3, ss.73-78, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 3
- Basım Tarihi: 2010
- Dergi Adı: Nobel Medicus
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.73-78
- Anahtar Kelimeler: Apoptosis, Cryptorchidism, Fertility, HCG, Hormone treatment
- Maltepe Üniversitesi Adresli: Evet
Özet
• Objective: Histopathological outcome of hcg treatment and the correlation of testicular apoptosis caused by hormone treatment with fertility potential were evaluated in an experimental cryptorchidism model in rats. • Material and Method: Three main groups of healthy, male, Sprague-Dawley rats, aged 22 days were were divided into three main groups Sham-operated (SO), experimental cryptorchidism (EC), and hormone treated EC groups (HT). Each main group was also divided into early and late orchidectomy groups to investigate early and late changes in the testis. Each group contained 10 rats. Eight and 30 days after first surgery, left orchidectomy was performed in all rats. All groups were compared to each other in terms of apoptosis (AI) and fertility index (FI). The relationship between AI and FI was evaluated with Pearson correlation coefficient. • Results: AI in HT group was lower than EC group in both periods; the difference was statistically significant in late period while it was not so in early period. FI in both EC and HT groups was significantly smaller than SO group in late period. Although FI was numerically smaller in HT than EC group in early and late periods, the difference was statistically insignificant. No consistent correlations between AI and FI could be shown. • Conclusion: No significantly increased negative effect, neither a beneficial effect of hCG treatment in terms of AI and FI respectively could be shown in our study. Also our findings suggest that AI at a certain time point is not a reliable indicator of future fertality potential of that individual.