Ratios of homocysteine and nitrite to high-density lipoprotein in coronary artery patients with the different degree of stenosis
Vascular Pharmacology, cilt.41, sa.3, ss.91-96, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 3
- Basım Tarihi: 2004
- Doi Numarası: 10.1016/j.vph.2004.07.002
- Dergi Adı: Vascular Pharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.91-96
- Anahtar Kelimeler: Cholesterol, Coronary artery disease, Homocysteine, Nitrite, Ratio
- Maltepe Üniversitesi Adresli: Evet
Özet
Although the interaction between Hcy, NO 2 - and vascular disease has been extensively studied, there are no data verifying their ratios to HDL-C in coronary artery disease (CAD). We examined whether Hcy/HDL-C and NO 2 -/HDL-C ratios correlated with the degree of stenosis in CAD. Also, TC/HDL-C and LDL-C/HDL-C ratios were evaluated in the same individuals. Seventy subjects were divided into three groups according to coronary angiography findings: >50% stenosis (n=35, years: 50.9±3.4; Group 1), 5-50% stenosis (n=20, years: 50.6±3.8; Group 2), <5% narrowing (n=15, years: 49.0±3.2; control group). Hcy/HDL-C, NO 2 -/HDL-C, TC/HDL-C and LDL-C/HDL-C were statistically higher in both Group 1 patients (p=0.001, for all ratios) and Group 2 patients (p=0.001, p=0.001, p=0.03, 0.041, respectively) with respect to controls. The values were correlated with the degree of stenosis in the different significance levels (r=0.496, p=0.001; r=0.384, p=0.004; r=0.334, p=0.012; r=0.321, p=0.016, respectively). In patients with >50% stenosis, NO 2 -/HDL-C was only shown to change significantly in relation to obstructive artery number (p=0.026) and also showed a positive correlation (r=0.379, p=0.032). In conclusion, Hcy/HDL-C and NO 2 -/HDL-C appear to be more indicative than TC/HDL-C and LDL-C/HDL-C in the evaluation of CAD patients regarding the degree of stenosis. However, only NO 2 -/HDL evaluation seems to be a reliable indicator in the patients with heavy stenosis of CAD. Further studies are needed to confirm the results of present study. © 2004 Elsevier Inc. All rights reserved.