The impact of FDG-PET for the preoperative management of patients with colorectal cancer FDG-PET'in kolorektal kanserli olgularda preoperatif hasta yönetimine etkisi
Balkan Medical Journal, cilt.28, sa.2, ss.133-137, 2011 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2011
- Doi Numarası: 10.5174/tutfd.2009.02767.2
- Dergi Adı: Balkan Medical Journal
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.133-137
- Anahtar Kelimeler: Colorectal cancer, FDG-PET, Patient management
- Maltepe Üniversitesi Adresli: Hayır
Özet
Objective: Whole-body fluorodeoxyglucose-positron emission tomography (FDG-PET) has proved effective in the diagnosis of recurrent colorectal cancer (CRC) and in the monitoring of cancer therapy. However there have been limited studies considering the effect of FDG-PET in the initial evaluation of CRC. We analysed how FDG-PET affects the management of patients with CRC preoperatively. Material and Methods: A prospective study of 26 consecutive patients with known or suspected CRC was undertaken. The patients were evaluated by computed tomography (CT) and FDG-PET. FDG-PET results were compared with those of CT and correlated with histopathologic findings or with clinical course. Results: FDG-PET had a sensitivity of 96% and positive predictive value of 100% for the diagnosis of primary cancer, while CT had values of 68% and 95%, respectively. FDG-PET was superior to CT in detecting additional metastatic disease with a sensitivity of 89%, while CT had 33%. FDG-PET resulted in altered management for 8 patients of whom three avoided inappropriate surgery. Conclusion: It is concluded that FDG-PET is highly sensitive for the diagnosis and staging of patients with CRC. Its use in conjunction with CT results in a more accurate selection of patients for surgical treatment with curative intent. © Trakya University Faculty of Medicine.