Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants
Journal of Perinatology, cilt.35, sa.1, ss.39-45, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.1038/jp.2014.146
- Dergi Adı: Journal of Perinatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.39-45
- Maltepe Üniversitesi Adresli: Evet
Özet
Objective:To evaluate the effect of vitamin D levels on early-onset sepsis (EOS) in term infants.Study Design:Fifty term infants with clinical and laboratory findings of EOS (study group) and 50 healthy infants with no signs of clinical/laboratory infection (control group) were enrolled. Blood was drawn at the time of admission during the first 3 postnatal days of life in both groups for measurement of 25-hydroxyvitamin D (25-OHD) levels.Result:Maternal and neonatal 25-OHD levels (22.2/8.6 ng ml -1, respectively) in the study group were significantly lower than those of the control group (36.2/19 ng ml -1, respectively, P<0.001). A positive correlation was detected between maternal and neonatal 25-OHD levels. Severe vitamin D deficiency was significantly more common in the sepsis group.Conclusion:Lower maternal and neonatal 25-OHD levels are associated with EOS. These data suggest that adequate vitamin D supplementation during pregnancy may be helpful to prevent EOS in term neonates.