Polyethylene terephthalate nanoplastics cause oxidative stress induced cell death in Saccharomyces cerevisiae
Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, cilt.59, sa.4, ss.180-188, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 4
- Basım Tarihi: 2024
- Doi Numarası: 10.1080/10934529.2024.2345026
- Dergi Adı: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, Environment Index, Greenfile, INSPEC, MEDLINE, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
- Sayfa Sayıları: ss.180-188
- Anahtar Kelimeler: cell death, Nanoplastics, oxidative stress, polyethylene terephthalate, Saccharomyces cerevisiae
- Maltepe Üniversitesi Adresli: Evet
Özet
Polyethylene terephthalate (PET) is a common plastic widely used in food and beverage packaging that poses a serious risk to human health and the environment due to the continual rise in its production and usage. After being produced and used, PET accumulates in the environment and breaks down into nanoplastics (NPs), which are then consumed by humans through water and food sources. The threats to human health and the environment posed by PET-NPs are of great concern worldwide, yet little is known about their biological impacts. Herein, the smallest sized PET-NPs so far (56 nm) with an unperturbed PET structure were produced by a modified dilution-precipitation method and their potential cytotoxicity was evaluated in Saccharomyces cerevisiae. Exposure to PET-NPs decreased cell viability due to oxidative stress induction revealed by the increased expression levels of stress response related-genes as well as increased lipid peroxidation. Cell death induced by PET-NP exposure was mainly through apoptosis, while autophagy had a protective role.