The comparison of 6- and 12-core first prostate biopsy results in patients with prostate specific antigen level of 4-10 ng/ml Prostat spesifik antijen deǧeri 4-10 ng/ml arasında olan hastaların 6- ve 12-kor ilk biyopsi sonuçlarının karşılaştırılması
Turk Uroloji Dergisi, cilt.35, sa.4, ss.274-280, 2009 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 4
- Basım Tarihi: 2009
- Dergi Adı: Turk Uroloji Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.274-280
- Anahtar Kelimeler: Biopsy, Diagnosis, Prostate, Prostate-specific antigen, Prostatic neoplasms
- Maltepe Üniversitesi Adresli: Evet
Özet
Objective: To compare 6- or 12-core first biopsy results in the prostate and to determine the relationship between biopsy core number and percentage of cancer detected. Materials and methods: Prostate biopsy results of the patients in our clinic were investigated retrospectively for the last five years. Patients with prostate specific antigen (PSA) level of 4-10 ng/mL and first line biopsies were included in the study. Standard biopsy procedure was applied as 6- or 12-cores. Age, PSA level, free PSA ratio, digital rectal examination (DRE) results, prostate volume measured by transrectal ultrasonography, percentage of cancer detected, and their distribution according to Gleason scores were investigated. Results: The results of 383 biopsies were evaluated. The mean age was 66 years, prostate volume was 50 cc, PSA level was 6 ng/mL, and free/total PSA ratio was 17%. Although the percentage of cancer detection was higher in 12-core biopsies than 6-core (21.5% vs. 25.3%), this difference was not statistically significant. In multivariate analysis, PSA and DRE findings were identified as fac- tors affecting cancer detection. In patients with prostate volume of 30-60 cc, cancer detection rate was higher in 12-core biopsy group, but similar in other volumes. Conclusion: In patients with PSA level of 4-10 ng/mL, prostate volume is <30 cc, and DRE findings are positive; 6-core first prostate biopsy is sufficient. When prostate volume is between 30-60 cc, 12-core biopsy is essential, but for prostate volume over 60 cc, the difference between 6- and 12-core is insignificant, thus additional core biopsy is necessary.