Evaluation of the mir-126, mir-182, and mir-486-5p expression signature of head and neck squamous cell carcinomas and lung squamous cell carcinomas
Turk Patoloji Dergisi, cilt.37, sa.2, ss.106-114, 2021 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.5146/tjpath.2021.01528
- Dergi Adı: Turk Patoloji Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.106-114
- Anahtar Kelimeler: Head and neck, Lung, Mir-126, Mir-182, Mir-486-5p, Squamous cell carcinoma
- Maltepe Üniversitesi Adresli: Evet
Özet
Objective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal SCCs in 40 patients, using quantitative real-time polymerase chain reaction. Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization. Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. miRNA expression analysis can be used to predict the primary localizations of those SCCs.