Penetration of ciprofloxacin into pleural fluid

Umut, SEMA; Demir, T.; Akkan, G.; Keskiner, N.; Yilmaz, V.; Yildirim, N.; Sipahioglu, B.; Hasan, A.; Barlas, A.; Sozer, K.; Ozuner, Z.

doi:10.1080/1120009x.1993.11739217

Penetration of ciprofloxacin into pleural fluid

Umut S., Demir T., Akkan G., Keskiner N., Yilmaz V., Yildirim N., ...Daha Fazla

Journal of Chemotherapy, cilt.5, sa.2, ss.110-112, 1993 (Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5 Sayı: 2
Basım Tarihi: 1993
Doi Numarası: 10.1080/1120009x.1993.11739217
Dergi Adı: Journal of Chemotherapy
Derginin Tarandığı İndeksler: Scopus
Sayfa Sayıları: ss.110-112
Anahtar Kelimeler: ciprofloxacin, plasma concentration, pleural effusion
Maltepe Üniversitesi Adresli: Hayır

Özet

The penetration of oral 1000 mg/day ciprofloxacin into pleural fluid is investigated in 15 patients with exudative pleural effusion. After 4 days of ciprofloxacin therapy ciprofloxacin concentrations were measured in plasma and pleural exudate simultaneously by high-performance liquid chromatography (HPLC). Mean serum ciprofloxacin level was 1.58 ± 0.91 mg/L and mean pleural exudate concentration was 1.00 ± 0.59 mg/L. The concentrations achieved were all above the MIC90 of the majority of Gram-positive and Gram-negative pathogens. It is concluded that ciprofloxacin penetrates well into the pleural fluid.