Effects of estradioldrospirenone on ocular and nasal functions in postmenopausal women

Coksuer H., ÖZCURA F., Oghan F., Haliloglu B., Coksuer C.

Climacteric, cilt.14, sa.4, ss.482-487, 2011 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/13697137.2010.539724
  • Dergi Adı: Climacteric
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.482-487
  • Anahtar Kelimeler: Angeliq, Drospirenone, Dry eye, Hormone replacement therapy, Nasal airflow, Ocular disease
  • Maltepe Üniversitesi Adresli: Evet

Özet

Background Hormones may have an impact on the incidence and course of dry-eye syndrome, and also nasal obstruction, especially in postmenopausal women. The aim of this study was to investigate the effects of drospirenone 2mg+estradiol 1mg (Angeliq® Bayer AG, Berlin, Germany) on ocular functions and nasal airflow in postmenopausal women. Methods Thirty-four postmenopausal women were recruited for the study. A questionnaire on ocular surface disease index (OSDI) was administered; after routine ophthalmologic examination, tear film break-up time (TBUT) and Schirmer tests were performed. Intraocular pressure was measured with a Goldmann applanation tonometer. Nasal airflow resistance values were measured using rhinomanometry. Participants were submitted to oral daily treatment with drospirenone 2mg+estradiol 1mg. The duration of the study was 6 months and the participants were studied in the basal condition and after 6 months of therapy. Results The OSDI score and intraocular pressure were significantly higher before treatment than after treatment (p<0.001); however, the results of the TBUT and Schimer test were significantly lower (p<0.05). Rhinomanometric values were better during drospirenone 2mg+estradiol 1mg therapy than those observed at baseline (p<0.001). Conclusions Oral daily treatment with drospirenone 2mg+estradiol 1mg reduces the risks for ocular diseases and nasal obstruction in postmenopausal women. © 2011 International Menopause Society.